Phenylpyrazine derivatives and thrombolytic agent

Details Phenylpyrazine derivatives and thrombolytic agent Phenylpyrazine derivatives and thrombolytic agent

1986-05-09

1988-07-05

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544336, 544410, A61K 31495, G07B24112

Patent

active

047555149

ABSTRACT:
Novel phenylpyrazine derivatives of the following general formula: ##STR1## (where R.sup.1 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a hydroxyl group; and R.sup.2 is a halogen atom, a lower alkyl group, a lower alkoxy group or a hydroxyl group) have a high degree of thrombolytic activity in comparison with a known thrombolytic agent, Ticlopidine. Moreover, their toxicities are very low. Therefore, the derivatives are extremely useful as thrombolytic agents.

REFERENCES:
Duenger, et al., Chem. Abstracts, vol. 73 (1970), entry 106474e.
Soldatenkov, et al, Chem. Abstracts, vol. 99 (1983), entry 175563g.
Tada, et al, Chem. Abstracts, vol. 94 (1981), entry 46467b.
Soldatenkov, A. T., Bagdadi, M. V., Radzhan, P. K., Brindkha, O. S., Edogiaverie, S. L., Fomichev, A. A. and Prostakov, N. S., Plenum Publishing Corporation, (Translated from Zhurnal Organicheskoi Khimii, vol. 19, No. 6, pp. 1326-1332, Jun. 1983).
Dunger South African Patent Appln 69-6582 dtd Sep. 1, 1969.
Chemistry Letters, Aug. 1980, pp. 921-924, The Chemical Society of Japan, M. Tada et al.

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