Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-03-29
1996-08-20
Shippen, Michael L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
560170, A61K 31225
Patent
active
055479863
ABSTRACT:
The L-carnitine ester with gamma-hydroxybutyric acid and its pharmacologically acceptable salts of formula (I) ##STR1## wherein X.sup.- is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate are active in inhibiting neuronal degeneration (as it occurs in Alzheimer's senile dementia and Parkinson's disease) and in the treatment of coma.
REFERENCES:
patent: 4439438 (1984-03-01), Cavazza
patent: 5041643 (1991-08-01), Tinti et al.
Fischer, Ann. Rev. Pharmacol. Toxicol., 26, pp. 161-181 (1986).
Smith, Brain Research Reviews, 13, pp. 103-118 (1988).
Verloes, Psychopharmacology, 95, pp. 226-230 (1988).
Schindler, Prog. Neuro-Psychopharmacol. & Biol. Psychiat., 13, pp. S99-S115, (1988).
"Conn's Current Therapy," Edited by Rakel, pp. 803-807 & 880-886 (1992).
"Cecil Textbook of Medicine," 19th Ed., Edited by Wyngaarden, et al., pp. 2047-2059, 2075-2079 & 2130-2133 (1992).
Cavazza Claudio
Misiti Domenico
Tinti Maria O.
Shippen Michael L.
Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
LandOfFree
Ester of L-carnitine with gamma-hydroxybutyric acid and pharmace does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ester of L-carnitine with gamma-hydroxybutyric acid and pharmace, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ester of L-carnitine with gamma-hydroxybutyric acid and pharmace will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2331074