Substituted 1-oxo-1,2-dihydroisoquinolinoylguanidines and 1,1-di

Details Substituted 1-oxo-1,2-dihydroisoquinolinoylguanidines and 1,1-di Substituted 1-oxo-1,2-dihydroisoquinolinoylguanidines and 1,1-di

1994-12-22

1996-08-20

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514309, 546141, 544 49, C07D21722, C07D27902, A61K 3147, A61K 3154

Patent

active

055479537

ABSTRACT:
Substituted 1-oxo-1,2-dihydroisoquinolinoylguanidines and 1,1-dioxo-2H-1,2-benzothiazinoylguanidines, a process for their preparation, their use as medicament or diagnostic agent, and also a medicament containing them. Acylguanidines I ##STR1## with X equal to carbonyl or sulfonyl; R(1) equal to H, (cyclo)alkyl, phenyl; R(2) equal to H, alkyl, and their pharmaceutically suitable salts, are described. They are obtained by reacting a compound II ##STR2## with guanidine. The compounds have no unwanted salidiuretic but very good antiarrhythmic properties. They are able, as a consequence of inhibition of the cellular Na.sup.+ /H.sup.+ exchange mechanism, to be used for the treatment of all acute or chronic ischemia-induced damage.

REFERENCES:
patent: 3780027 (1973-12-01), Cragoe et al.
patent: 5091394 (1992-02-01), Englert et al.
patent: 5373024 (1994-12-01), Lang et al.
patent: 5416094 (1995-05-01), Lal et al.

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