Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound other than saccharide containing a...
Patent
1992-09-23
1996-08-20
Jones, W. Gary
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound other than saccharide containing a...
435 691, 435 914, 435 9141, 4352402, 4352523, 435267, 435 6, 536 235, 536 245, 424 931, 424 932, 424 936, 424520, 935 32, 935 57, 935 71, C12Q 170, C07H 2104, A01N 6300, C12N 1500
Patent
active
055479324
ABSTRACT:
A composition for the transfection of higher eucaryotic cells, comprising complexes of nucleic acid, a substance having an affinity for nucleic acid and optionally an internalizing factor, contains an endosomolytic agent, e.g. a virus or virus component, which may be conjugated. The endosomolytic agent, which is optionally part of the nucleic acid complex, is internalized into the cells together with the complex and releases the contents of the endosomes into the cytoplasm, thereby increasing the gene transfer capacity. Pharmaceutical preparations, transfection kits and methods for introducing nucleic acid into higher eucaryotic cells by treating the cells with the composition are also disclosed.
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Birnstiel Max L.
Cotten Matthew
Curiel David T.
Oberhauser Berndt
Plank Christian
Boehringer Ingelheim International GmbH
Genentech Inc.
Jones W. Gary
Sisson Bradley L.
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