Process for the preparation of a 2-substituted 3,3-difluorofuran

Details Process for the preparation of a 2-substituted 3,3-difluorofuran Process for the preparation of a 2-substituted 3,3-difluorofuran

1995-03-24

1997-05-27

Gupta, Yogendra N.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 221, 536 283, 536 284, 536 2851, 536 2852, 536 2853, 536 2854, 549429, 549475, C07H 1906

Patent

active

056333676

ABSTRACT:
A process for the preparation of a 2-substituted-3,3-difluorofuran using diethyl ammonium sulfur trifluoride (DAST) and pyridine hydrogen fluoride. The process is particularly useful for producing a 2',2'-difluoronucleoside, particularly 1-(2',2'-difluoro-.beta.-D-arabinofuranosyl)cytosine (also known as 2'-deoxy-2',2'-difluorocytidine), a known antiviral and antitumor agent.

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