Chemistry: natural resins or derivatives; peptides or proteins; – Lignins or derivatives – Aldehyde – ketone or ozone reacted with a lignin or lignin...
Patent
1994-02-14
1998-01-06
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Lignins or derivatives
Aldehyde, ketone or ozone reacted with a lignin or lignin...
4241881, 4242081, C07K 100, C07K 1400, C07K 1700, A61K 3921
Patent
active
057056129
ABSTRACT:
The complete nucleotide sequence of a proviral molecular clone of the lymphadenopathy-associated virus, LAV, was ascertained. Recombinant phage clones were isolated from a genomic library of LAV-infected human T-lymphocyte DNA. The insert of recombinant phase .lambda.J19 was sequenced according to the dideoxy chain termination method. In addition to the retroviral structural genes gag, pol, and env, a novel open reading frame (ORF) was identified in the 3' region of the viral genome and designated ORF-R. The ORF-R coding region, which has subsequently been renamed nef, encodes a 206 amino acid protein that slightly overlaps the 3' end of the env gene and the 5' portion of the U3 region of the viral long terminal repeat (LTR). Nucleic acids encoding this protein and the precise amino acid sequence of the Nef are disclosed in this application. These products are useful for the generation of immunological reagents to facilitate the detection of LAV.
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Alizon Marc
Danos Oliver
Sonigo Pierre
Stewart Cole
Wain-Hobson Simon
Institut Pasteur and Centre National de la Recherche Scientifiqu
Nucker Christine M.
Parkin Jeffrey S.
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