Method for reducing intraocular pressure in the mammalian eye by

Details Method for reducing intraocular pressure in the mammalian eye by Method for reducing intraocular pressure in the mammalian eye by

1996-09-23

1998-01-06

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514569, 514737, 514516, 514912, 514913, 424 7804, A61K 31195

Patent

active

057055300

ABSTRACT:
Pharmaceutical compositions and a method are disclosed for treating glaucoma and/or ocular hypertension in the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the invention which contains, as the active ingredient, one or more compounds having chloride channel blocking activity. Examples of chloride channel blockers utilized in the pharmaceutical composition and method of treatment are: ##STR1## wherein R is hydrogen or a pharmaceutically-acceptable cation, e.g. an alkali or alkaline earth metal, or a quaternary amine; or R represents a ester-forming moiety, e.g. a lower alkyl radical, having up to six carbon atoms, that may be derived from a lower alkanol.

REFERENCES:
patent: 4981871 (1991-01-01), Abelson
patent: 4994493 (1991-02-01), Greger et al.
patent: 5435998 (1995-07-01), Abelson

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