Aplha-substituted-3-benzyl-benzofurans

Details Aplha-substituted-3-benzyl-benzofurans Aplha-substituted-3-benzyl-benzofurans

1995-09-29

1998-01-06

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546196, 546187, 514469, 5142335, 514422, 514212, 514316, 5142325, 549467, 549469, 549471, 549470, 544153, 544 76, 548525, 540596, 540597, 206828, C07D30781, C07D40712, C07D40512, A61K 3134

Patent

active

057055076

ABSTRACT:
This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzofurans which are .alpha.-substituted with ether, thioether, amino, hydrazino, cyano or halo that are useful for the treatment of the various medical indications associated with post-menopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus and cervix. The present invention further relates to intermediate compounds and processes useful for preparing the pharmaceutically active compounds of the present invention, and pharmaceutical compositions.

REFERENCES:
patent: 4133814 (1979-01-01), Jones et al.
patent: 4380635 (1983-04-01), Peters
patent: 4418068 (1983-11-01), Jones
patent: 4806663 (1989-02-01), Kennedy et al.
patent: 4851554 (1989-07-01), Kennedy et al.
patent: 5354861 (1994-10-01), Sim et al.
Durani, et al, Journal of Medical Chemistry, vol. 32, No. 8, Aug. 1989, pp. 1700-1707.

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