Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-06
1997-05-27
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548200, C07D27706, A61K 31425
Patent
active
056332700
DESCRIPTION:
BRIEF SUMMARY
DESCRIPTION OF THE INVENTION
The present invention relates to derivatives of formula: ##STR2## and to their salts, their preparation and medicinal products containing them.
In the formula (I): 12 carbon atoms and optionally mono- or polyunsaturated, a cycloalkyl radical containing 3 to 12 carbon atoms and optionally mono- or polyunsaturated, a polycycloalkyl radical containing 6 to 12 carbon atoms and optionally mono- or polyunsaturated, a phenylalkyl radical in which the phenyl ring is optionally substituted (with one or more substituents chosen from alkyl and alkoxy radicals or halogen atoms), a diphenylalkyl or cinnamyl radical, a pyridyl radical optionally substituted with one or more alkyl radicals, a furyl radical optionally substituted with one or more alkyl radicals, a thienyl radical optionally substituted with one or more alkyl radicals, a quinolyl radical optionally substituted with one or more alkyl radicals, a naphthyl radical optionally substituted with one or more alkyl radicals, an indolyl radical optionally substituted with one or more alkyl radicals, a 2-oxopiperidyl or quinuclidinyl radical or a phenyl radical optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, hydroxyl, nitro, amino, monoalkylamino, dialkylamino, alkoxycarbonyl, --CO--NR.sub.7 R.sub.8, --NH--CO--CH.sub.3, trifluoromethyl, phenyl or trifluoromethoxy radicals, radical or a phenyl radical optionally substituted with one or more substituents chosen from halogen atoms and alkyl and alkoxy radicals, --(CH.sub.2).sub.m --O--CO--R".sub.6 or --(CH.sub.2).sub.m --NR.sub.9 R.sub.10, an oxazolinyl radical optionally substituted with one or more alkyl radicals or a 3-alkyloxadiazolyl radical, radical or a phenyl radical optionally substituted with one or more substituents chosen from halogen atoms and alkyl and alkoxy radicals, more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals), a naphthyl, indolyl or quinolyl radical or a phenylamino radical in which the phenyl ring is optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy, alkylthio, trifluoromethyl, carboxyl, alkoxycarbonyl, hydroxyl, nitro, amino, acyl, cyano, sulphamoyl, carbamoyl, hydroxyiminoalkyl, alkoxyiminoalkyl, hydroxyaminocarbonyl, alkoxyaminocarbonyl, 5-tetrazolyl, 5-tetrazolylalkyl, trifluoromethylsulphonamido, alkylsulphinyl, mono- or polyhydroxyalkyl, sulpho, - --alk--O--CO--alk, --alk--COOX, --alk--O--alk, --alk'--COOX, --O--alk--COOX, --CH.dbd.CH--COOX, COOX, --alk--SO.sub.3 H (in salt form), --CH.dbd.CH--alk', --C(.dbd.NOH)-- COOX, --S--alk--COOX, --SO--alk--COOX, --SO.sub.2 --alk--COOX, --O--CH.sub.2 --alk'--COOX, --CX.dbd.N--O--alk--COOX, --alk--N(OH)--CO--alk, --alk--SO.sub.2 H, --SO.sub.2 --NH--CO--R.sub.11, --SO.sub.2 --NH--SO.sub.2 --R.sub.11, --CO--NH--CO--R.sub.11, --CO--NH--SO.sub.2 --R.sub.11, --B(OH).sub.2, --C(NH.sub.2).dbd.NOH, --SO.sub.2 --NH--R.sub.12, --CO--NH--R.sub.12, ##STR3## or 2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl radicals, R.sub.6 represents a hydroxyl, alkoxy, cycloalkyloxy, cycloalkylalkyloxy or phenyl radical or a radical --NR.sub.9 R.sub.10, radical or a radical --NR.sub.9 R.sub.10, phenyl radical optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, are attached, form a saturated or unsaturated mono- or polycyclic heterocycle containing 4 to 9 carbon atoms and one or more hetero atoms (O, N) and optionally substituted with one or more alkyl radicals, or phenylalkyl radical or a phenyl radical optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, radical or a phenyl radical optionally substituted with one or more substituents chosen from halogen atoms and alkyl, alkoxy and alkylthio radicals, or alternatively R.sub.9 and R.sub.10, together with the nitrogen atom t
Dubroeucq Marie-Christine
Manfre Franco
Gerstl Robert
Rhone-Poulenc Rorer S.A.
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