Process for selective preparation of ratios of isomers formed on

Details Process for selective preparation of ratios of isomers formed on Process for selective preparation of ratios of isomers formed on

1985-10-02

1987-12-08

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23390

Patent

active

047119624

ABSTRACT:
Novel processes are disclosed for selectively preparing a mixture of certain asymmetric imidazole derivatives and their corresponding regioisomers. The process involves reacting a tautomeric mixture of two precursor compounds with a critical base in the presence of a critical solvent, prior to the desired N-substitution reaction. In general, the base is a hydride of an alkali metal or an alkaline earth metal, or mixtures thereof. Sodium hydride is particularly suitable. The solvents are all non-polar.

REFERENCES:
patent: 4039543 (1977-08-01), Kompis et al.
patent: 4571257 (1986-02-01), Leone-Bay et al.
Grimmett, M., Adv. Het. Chem., vol. 27, Academic Press, New York, 1980, pp. 288-297.
Grimmett, M., Adv. Het. Chem., vol. 12, Academic Press, New York, 1970, p. 164.
Hofmann, K., Imidazole and its Derivatives, Part I, Interscience, New York, 1953, pp. 26-30.

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