Intermediates for cyclobutenedione substituted (1-carba)cephalos

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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540215, 540222, 540221, C07D50118

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active

052063607

ABSTRACT:
A compound of formula I ##STR1## wherein X is sulfur or CH.sub.2 ;

REFERENCES:
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patent: 4508717 (1985-04-01), Berger
patent: 5106842 (1992-04-01), Hudyma et al.
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Fahey, et al., Journal of Medicinal Chemistry, 19, 4, p. 562 (1976) "3-Cyanocephems, and Carbon-13 Heterocyclic-Substituted Cephems via 1,3-Dipolar Cycloadditions".
Sugawara, et al., Chem. Parm. Bull., 28, 7, p. 2116 (1980) "Synthesis of Cephalosporins with Substituted Thiadiazoles directly attached to the C-Position".
Hornback, et al., Copy of Abstract No. 153 and hand out from the 200th American Chemical Society meeting in Washington, D.C., Aug. 26-31, 1990.
Farina, et al., The Journal of Organic Chemistry, 54, 20, p. 4962 (1989) "A General Route to 3-Functionalized 3-Norcephalosporins".
Hatanaka, et al., Tetrahedron Letters, 24, 44, p. 4837 (1983) "A Simple Synthesis of (.+-.)-1-Carbacephem Derivatives".
Farina, et al., Tetrahedron Letters, 29, 47, p. 6043 (1988) "Palladium Catalysis in Cephalosporin Chemistry: A versatile new approach to 3-substituted cephems".
Cook, et al., The Journal of Organic Chemistry, 54, p. 5828 (1989) "Palladium-Catalyzed Chemistry of .beta.-Lactam Vinyl Triflates".

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