Preparation of functional human factor VIII

Details Preparation of functional human factor VIII Preparation of functional human factor VIII

1990-10-09

1997-05-27

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435325, 4352523, 4353201, 435352, 530383, 536 235, 930100, C12N 510, C12N 1512, C07K 14755, A61K 3837

Patent

active

056331509

ABSTRACT:
Functional human factor VIII produced recombinantly is used in the treatment of human beings diagnosed to be deficient in factor VIII coagulant activity. Also provided are DNA isolates and expression vehicles encoding functional human factor VIII, as well as transformed host cells and processes for producing human factor VIII by use of recombinant DNA technology.

REFERENCES:
patent: Re32011 (1985-10-01), Zimmerman et al.
patent: 4027013 (1977-05-01), Dick et al.
patent: 4069216 (1978-01-01), Shanbrom
patent: 4085095 (1978-04-01), Dick et al.
patent: 4093608 (1978-06-01), Iga et al.
patent: 4104266 (1978-08-01), Wickerhauser
patent: 4188318 (1980-02-01), Shanbrom
patent: 4221780 (1980-09-01), Cort
patent: 4289691 (1981-09-01), Rock et al.
patent: 4294826 (1981-10-01), Feldman
patent: 4341764 (1982-07-01), Wallace et al.
patent: 4348315 (1982-09-01), Blomback et al.
patent: 4359463 (1982-11-01), Rock
patent: 4361509 (1982-11-01), Zimmerman et al.
patent: 4387092 (1983-06-01), Liautaud et al.
patent: 4396601 (1983-08-01), Salser et al.
patent: 4399216 (1983-08-01), Axel et al.
patent: 4404131 (1983-09-01), Schwarz et al.
patent: 4495175 (1985-01-01), Chavin et al.
patent: 4508709 (1985-04-01), Amphlett
patent: 4522751 (1985-06-01), Linnaw et al.
patent: 4556558 (1985-12-01), Rubinstein
patent: 4614795 (1986-09-01), Chavin et al.
patent: 4632981 (1986-12-01), Bock et al.
patent: 4657894 (1987-04-01), Zimmerman et al.
patent: 4659805 (1987-04-01), Schilling et al.
patent: 4757006 (1988-07-01), Toole, Jr. et al.
patent: 4879226 (1989-11-01), Wallace et al.
patent: 4965199 (1990-10-01), Capon et al.
patent: 5004804 (1991-04-01), Kuo et al.
patent: 5101016 (1992-03-01), Zimmerman et al.
Schuner, et al. Nucl. Acids Res. 4:6601-6605 (1981).
Choo, et al. DNA 5(6):524-537 (1986).
Norris, et al. Nucl. Acids Res. 11:5103-5112 (1983).
Orr, et al. Thrombosis Haemostasis 154(1):54 (1985).
Eaton, D. et al.Biochemistry 25:505-512 (1986).
Andersson, et al. PNAS 83:2474-2483 (1986).
Robert J. Harris, "Isolation & Characterization of Low Molecular Weight, Non-Aggregated Antihemophilic Factor from Fresh Human Plasma", 1979 Dissertation Abstract.
John J. Toole, et al., "A large Region (95kDa) of human factor VIII is dispensable for in vitro procoagulant activity" (1986), 5939-5942, Proc. Natl. Acad. Sci. USA., vol. 88 Aug. 1986.
Randal J. Kaufman, et al. "Site-Specific Mutagenesis to Study the Structure and Function of Factor VIII", Jan. 20-Feb. 15, 1986, p. 275, Journal of Cellular Biochemistry, Supplement 10A, 1986, UCLA Sumposia on Molecular & Cellular Biology, Alan R. Liss, Inc., New York.
Fass et al., Blood, 59(3):594-600 (1982).
Stel et al., Nature, 303:530-532 (1983) (Abstract Only).
Hoyer & Trabold, J. Lab. & Clin. Med., 97(1):50-64 (1981).
Nexis Report, Business Week (Feb. 16, 1987).
Nexis Report, Genetic Technology News (Nov. 1987).
Nexis Report, Business Week (Apr. 13, 1987).
FDC Reports, 50(18): T&G-12 (May 2, 1988).
Fau, P.J et al., Proc. Natl. Acad. Sci. USA, 79:7200-7204 (Dec. 1982).
Knutson, G.J. & Fass, D.N., Blood, 59(3):615-624 (Mar. 1982).
de Saint Vincent, et al., Cell, 27:267-277. (1981).
U S Conlogue, et al., Proc. Natl. Acad. Sci. USA, 81:540-544 (1984).
Kaufman, et, al., Proc. Natl. Acad. Sci. USA, 83:3136-3140 (1986).
Kempe, et al., Cell, 9:541-550 (1976).
Wahl, et al., Nature, 307:516-520 (1984).
Milbrandt, et al., Molecular and Cellular Biology, 3(7):1274-1282 (1983).
Murray et al, Mol. & Cell. Biol., 3(1):32-43 (1983).
Wigler et al., PNAS USA, 77(6):3567-3570 (1980).
Zimmerman et al., In Haemostasis and Thrombosis, Bloom et al., ed. p. 111 (1981).
Biotechnology Law Report, vol. 6, pp. 389-390 (Sep.-Oct. 1987).
Newswatch, Nov. 2, 1987, pp. 5-6, vol. 7, No. 21.
Brownlee et al., Nature 312:307 (Nov. 1984).
Maddox, J. Nature 312:306 (Nov. 1984).
Fulcher, C.A., et al., Proc. Natl. Acad. Sci. USA 79: 1648-1652 (Mar. 1982).
Vehar, G.A. et al., Biochemistry 19(3):401-410 (Feb. 1980).
Weinstein, M.J. et al., "Blood" 62(5): 1114-1117 (Nov. 1983).
Fay et al., "Biochimica Et Biophysica Acta" 800:152-158 (1984).
Fay et al., Science 232:995-998 (May 1986).
Fay et al., Biochimica Et Biophysica Acta 871:268-278 (1986).
Legaz, M.E. et al., "J. Biol. Chem." 248:(11):3946-3955 (1973).
Gitschier et al., Nature 312:326-30 (1984).
Wood et al., Nature 312:330-37 (1984).
Vehar et al., Nature 312:337-42 (1984).
Toole et al., Nature 312:342-47 (1984).
Wigler et al., Cell 16:777-785 (1979).
Kaufman et al., J. Mol. Biol. 159:601-621 (1982).
Kaufman et al., Mol. Cell. Biol. 2(11): 1304-1319 (1982).
Haber et al., Somatic Cell Gen. 8(4): 499-508 (1982).

Affiliated with

Also associated with

Rating

Preparation of functional human factor VIII does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of functional human factor VIII, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of functional human factor VIII will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2328427