Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-08-05
1998-01-06
Rories, Charles C.P.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435375, 435377, 536 231, 536 243, 536 2431, 536 2432, 536 245, 530300, 530333, 436 86, 436 94, C12Q 168, C07H 2100, C07K 700, C07K 100
Patent
active
057053332
ABSTRACT:
The present invention provides novel nucleic acid mimics (termed "PENAMs") comprising a peptidic backbone and nucleotidic sidechains; the sidechains being oriented in such a way that the PENAM is homomorphous to target nucleic acids with which it can effectively hydrogen bond. Homomorphism is achieved by the incorporation of unusual sterochemical centers, including D-chiral centers and quasi-chiral centers, into the peptidic backbone. The PENAMs are useful for targeting nucleic acid sequences in order to modulate their activity in an "antisense" manner. Targeting can also be used to detect, isolate or modify target nucleic acids.
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Kenyon George L.
Kuntz Irwin D.
Shah Vibhakar J.
Rories Charles C.P.
The Regents of the University of California
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