Microcapsules prepared from crosslinkable polysaccharides, polyc

Details Microcapsules prepared from crosslinkable polysaccharides, polyc Microcapsules prepared from crosslinkable polysaccharides, polyc

1995-06-07

1998-01-06

Berman, Susan W.

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Particulate matter

522 87, 522 88, 522 89, 522 75, 527313, 527314, 424493, 424497, B32B 516, C08G 6908, C08L 500

Patent

active

057052700

ABSTRACT:
The present invention relates to a new form of biocompatible materials (e.g., lipids, polycations, polysaccharides) which are capable of undergoing free radical polymerization, e.g., by using certain sources of light; methods of modifying certain synthetic and naturally occurring biocompatible materials to make polymerizable microcapsules containing biological material coated with said polymerizable materials, composites of said polymerizable materials, methods of making microcapsules and encapsulating biological materials therein, and apparatus for making microcapsules containing biological cells (particularly islets of Langerhans) coated with polymerizable alginate or with a composite thereof (e.g., alginate and PEG). The present invention also relates to drug delivery systems relating to the foregoing, as well as bioadhesives and wound dressings made utilizing the foregoing technology.

REFERENCES:
patent: 4138292 (1979-02-01), Chibata et al.
patent: 4450233 (1984-05-01), Mimura et al.
patent: 4652441 (1987-03-01), Okada et al.
patent: 5149543 (1992-09-01), Cohen et al.
patent: 5334640 (1994-08-01), DeSai et al.
patent: 5529914 (1996-06-01), Hubbell et al.
Smidsrod et al, "Alginate as Immobilization Matrix for Cells", Tibtech, pp. 71-78, Mar. 1990.
Goosen et al, "Optimization of Microencapsulation Parameters:Semipermeable Microcapsules as a Bioartificial Pancreas", Biotech. & Eng. vol. XXVII, pp.146-150, 1985.

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