Method for reducing emotional lability

Details Method for reducing emotional lability Method for reducing emotional lability

1992-03-27

1993-04-27

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514282, 514305, A61K 3144

Patent

active

052062481

ABSTRACT:
This invention discloses that certain types of non-addictive opioid drugs such as dextromethorphan (which is widely used in cough syrups) provide a highly effective means of treating the feelings and symptoms of emotional lability in at least some patients suffering from neurologic impairment, without sedating, tranquilizing, or otherwise significantly interfering with consciousness or alertness in the patient. In several patients tested to date who were suffering from amyotrophic lateral sclerosis (ALS), dextromethorphan, administered orally, was remarkably effective and became quite obvious to the patients even though it was being tested for an entirely different purpose. Its effectiveness is enhanced by co-administration of a second drug such as quinidine which reduces the degradation of dextromethorphan by oxidative enzymes and which therefore increases dextromethorphan concentrations in the blood.

REFERENCES:
N. H. Kalin et al, "Opiate modulation of separation-induced distress in non-human primates," Brain Research 440: 285-292 (1988).
M. D. Nielsen et al, "A dose-effect study of the in vivo inhibitory effects of quinidine . . . " Br. J. Clin Pharmac. 29: 299-304 (1990).
F. Broly et al, "Inhibitory studies of mexiletine and dextromethorphan oxidation . . . " Biochem. Pharmacology 39: 1045-1052 (1990).
CA 108: 124860y, Kalin et al., 1988.
CA 112: 171691m, Due Nielsen et al., 1990.
CA 112: 210493v, Broly et al., 1990.

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