Nucleotide or nucleoside photoaffinity compound modified antibod

Details Nucleotide or nucleoside photoaffinity compound modified antibod Nucleotide or nucleoside photoaffinity compound modified antibod

1994-03-11

1997-01-21

Scheiner, Toni R.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303913, 5303915, 5303917, 5303919, 436547, C07K 1600, C12P 2100

Patent

active

055960812

ABSTRACT:
Sites on antibodies having affinity for photoaffinity compounds, in particular purine or azidopurine containing compounds are taught. These sites provide for the site-specific attachment of nucleotide photoaffinity compounds to antibodies, e.g., ATP- or GTP-analog photoaffinity compounds by photochemical reaction. These nucleotide photoaffinity compounds may additionally be attached to molecules having a desired therapeutic or diagnostic activity, and the resultant conjugates used as diagnostics or therapeutics.

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