Variants of human corticosteroid binding globulin

Details Variants of human corticosteroid binding globulin Variants of human corticosteroid binding globulin

1995-04-14

1997-01-21

Hendricks, Keith D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530386, 530395, A61K 3704

Patent

active

055959695

ABSTRACT:
A novel steroid-binding variant of human corticosteroid binding globulin in which one or more of the glycosylation sites, other than the glycosylation site at amino acid position 238, has been functionally disrupted is complexed with an anti-inflammatory ligand in the treatment of inflammation in mammals.

REFERENCES:
patent: 4997814 (1991-03-01), Hammond
patent: 5086039 (1992-02-01), Hammond
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Hammond et al., "Primary Structure Of Human Corticosteroid Binding Globulin, Deduced From Hepatic And Pulmonary cDNAs, Exhibits Homology With Serin Protease Inhibitors", Proc. Natl. Acad. Sci., Aug. 1987, vol. 84, pp. 5153-5157.
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Hammond et al., "A Versatile Method For The Determination Of Serum Cortisol Binding Globulin And Set Hormone Binding Globulin Binding Capacities", Clinica Chimica Acta, 132, 1983, pp. 101-110.

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