Process for the preparation of fluorinated pyridine derivatives

Details Process for the preparation of fluorinated pyridine derivatives Process for the preparation of fluorinated pyridine derivatives

1985-10-04

1989-05-16

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546311, C07D21361

Patent

active

048311480

ABSTRACT:
In accordance with a novel process, 2,3-difluoropyridines of formula I ##STR1## wherein X is halogen or trifluoromethyl, are prepared by diazotising a 3-amino-2-halopyridine of formula II ##STR2## wherein X is as defined for formula I and Y is bromine, chlorine or fluorine, in the presence of hydrogen fluroide, to give a 3-fluoro-2-halopyridine of formula III ##STR3## wherein X and Y are as defined for formula II, and treating resultant 3-fluoro-2-halopyridines of formula III, wherein Y is bromine or chlorine, with a fluorinating agent.
The 2,3-difluoropyridines prepared by the novel process are valuable intermediates for the preparation of 2-[4-(3-fluoropyridin-2-yloxy)-phenoxy]propionic acid derivatives which are known as herbicides.

REFERENCES:
patent: 2563796 (1948-05-01), Shenk et al.
patent: 3703521 (1972-11-01), Bondakian
patent: 4031100 (1977-06-01), Giacobbe
patent: 4071521 (1978-01-01), Muench
patent: 4505743 (1985-03-01), Schurter et al.
Berrie, A. H. et al., J. Chem. Soc. 1952 pp. 2042-2046.
Derwent Abstract 54228A/30.
Derwent Abstract 46484B/25.
Derwent Abstract 84-027477/05.
Journal of Fluorine Chemistry, 18(1981) 497-506.
Atkins, P. W. "Physical Chemistry" (1978) pp. 225-228 W. H. Freeman and Company, San Francisco.
Chem. Abstracts, Misaki et al., vol. 81, p. 522 (1974) P.
Roe et al., J. Amer. Chem. Soc., 69, pp. 2443-2444 (1947).
Ferm et al., J. Amer. Chem. Soc., 72, pp. 4809-4811 (1950).

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