Pyrrolizidine compounds, and their use as antiarrhythmic agents

Details Pyrrolizidine compounds, and their use as antiarrhythmic agents Pyrrolizidine compounds, and their use as antiarrhythmic agents

1985-07-03

1989-05-16

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548453, C07D48704, A61K 31395

Patent

active

048310492

ABSTRACT:
A novel pyrrolizidine compound of the formula ##STR1## wherein R.sup.1 is an alkyl group of 1 to 4 carbon atoms or a phenyl group; and R.sup.2 and R.sup.3 are such that at least one of them is an alkyl group of 1 to 4 carbon atoms and the other, if not alkyl, being a hydrogen atom is produced by reacting .DELTA..sup.4(8) -dehydropyrrolizidine with a substituted malonic acid and the thus formed 2-substituted-8-pyrrolizidineacetic acid with a substituted aniline. The products are subjected to optical resolution and are potentantiarrhythmic agents.

REFERENCES:
patent: 4020094 (1977-04-01), Nelson et al.
patent: 4564624 (1986-01-01), Miyano et al.
patent: 4617401 (1986-10-01), Miyano et al.

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