Tetrazole derivatives of 1,3-dioxane and thromboxane A.sub.2 ant

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548252, 544109, 544366, 546210, 514255, 514340, 5142362, A61K 3141, C07D40506

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active

048310468

ABSTRACT:
The invention describes various novel tetrazole derivatives of the formula I in which R.sup.1 and R.sup.2 are independently hydrogen, trifluoromethyl or (1-6C)alkyl (but R.sup.1 and R.sup.2 is not greater than 6 carbon atoms), or R.sup.1 is optionally substituted phenyl and R.sup.2 is hydrogen, Y is vinylene, n is 1 or 2 and m is 1, 2 or 3, or a pharmaceutically acceptable salt thereof, for use in conjunction with their pharmaceutical compositions in the treatment of various pulmonary and/or vascular disorders. Also described are various processes and intermediates for the manufacture of the novel compounds.

REFERENCES:
patent: 3600437 (1971-08-01), Marshall
patent: 3883513 (1975-05-01), Hess et al.
Buchanan et al., J. of Med. Chem., 12, (1969), p. 1001.

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