Tricyclic-substituted piperidine antihistamines

Details Tricyclic-substituted piperidine antihistamines Tricyclic-substituted piperidine antihistamines

1984-04-25

1989-05-16

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514324, 514422, 546202, 548525, 549 44, 549 48, A61K 31445, C07D40908

Patent

active

048310425

ABSTRACT:
Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic ##STR3## is a six membered ring which is 2,3, or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ##STR4## is a nitrogen containing ring ##STR5## must be phenyl; Z is an alkylene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen, or a hydroxy group as a substituent; W is defined hereinbelow.

REFERENCES:
patent: 3464983 (1969-09-01), Jucker et al.
patent: 3862156 (1975-01-01), Bourquin et al.
patent: 4072756 (1978-02-01), Ebnother et al.
Chemical Abstracts, 83:164155u (1975) [Ger. Offen. 2,423,721, Ebnoether et al., 12/12/74].
March, J., Advanced Organic Chemistry, McGraw Hill, New York , 1968, pp. 928-930.
Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 6th ed., MacMillan, New York, 1980, p. 1555.
Central Patents Index Classified Alerting Bulletin, Section B, Farmdoe, 6/12/85, Abstract of EP 138,481, pp. 5-6.

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