Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Diagnostic or test agent produces in vivo fluorescence
Patent
1995-06-07
1997-01-21
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Diagnostic or test agent produces in vivo fluorescence
424 173, 424 96, 435 6, 436 98, 436177, 436800, 436905, 540145, 540465, 540472, C07D48722
Patent
active
055957269
ABSTRACT:
The present invention is directed to chromophoric probes for use in detecting nucleic acid sequences. More particularly, the invention is directed to probes that comprise a texaphyrin chromophore molecule covalently coupled or conjugated to a site-directing molecule, the site-directing molecule having affinity for a biological receptor or a nucleic acid sequence. In one embodiment of the invention, the probe comprises a texaphyrin chromophore conjugated to an oligonucleotide having complementary binding affinity for a target nucleic acid sequence.
REFERENCES:
patent: 4318825 (1982-03-01), Frame
patent: 4647447 (1987-03-01), Gries et al.
patent: 4835263 (1989-05-01), Nguyen et al.
patent: 4878891 (1989-11-01), Judy et al.
patent: 4880008 (1989-11-01), Lauffer
patent: 4883790 (1989-11-01), Levy et al.
patent: 4899755 (1990-02-01), Lauffer et al.
patent: 4915683 (1990-04-01), Sieber
patent: 4935498 (1990-06-01), Sessler et al.
patent: 4959363 (1990-09-01), Wentland
patent: 4977177 (1990-12-01), Bommer et al.
patent: 5021236 (1991-06-01), Gries et al.
patent: 5030200 (1991-07-01), Judy et al.
patent: 5041078 (1991-08-01), Matthews et al.
patent: 5141911 (1992-08-01), Meunier et al.
patent: 5162509 (1992-11-01), Sessler et al.
patent: 5242797 (1993-09-01), Hirschfeld
patent: 5252720 (1993-10-01), Sessler et al.
patent: 5256399 (1993-10-01), Sessler et al.
patent: 5272056 (1993-12-01), Burrows et al.
patent: 5272142 (1993-12-01), Sessler et al.
patent: 5292414 (1994-03-01), Sessler et al.
patent: 5302714 (1994-04-01), Sessler et al.
patent: 5369101 (1994-11-01), Sessler et al.
patent: 5371199 (1994-12-01), Therien et al.
patent: 5432171 (1995-07-01), Sessler et al.
patent: 5439570 (1995-08-01), Sessler et al.
patent: 5451576 (1995-09-01), Sessler et al.
patent: 5457183 (1995-10-01), Sessler et al.
Casas et al., "Preparation of Hybrid DNA Cleaver-Oligonucleotide Molecules Based on a Metallotris(methylpyridiniumyl)porphyrin Motif", Bioconjugate Chem., 4:366-371 (1993).
Abid et al., "Lanthanide Complexes of Some Macrocyclic Schiff Bases Derived from Pyridine-2,6-dicarboxaldehyde and .delta..omega.-Primary Diamines", Inorg. Chim. Acta, 95:119-125, 1984.
Acholla et al., "Binucleating Tetrapyrrole Macrocycles", J. Am. Chem. Soc., 107:6902-6908, 1985.
Acholla et al., "A Binucleating Accordian Tetrapyrrole Macrocycle", Tetrahedron Lett., 25:3269-3270, 1984.
Ansell, "X-Ray Crystal Structure of the Pentagonal Bipyramidal Nickel(11) Complex [Ni.sup.11 (L)(H.sub.2 O).sub.2 ](BF.sub.4).sub.2 and the Selective Stabilisation of the Nickel(1) Oxidation State by a Quinquedentate Macrocyclic Ligand", J. Chem. Soc., Chem. Commun. pp. 546-547, 1982.
Bauer et al., "Sapphyrins: Novel Aromatic Pentapyrrolic Macrocycles", J. Am. Chem. Soc., 105:6429-6436, 1983.
Broadhurst et al., "Preparation of Some Sulphur-containing Polypyrrolic Macrocycles. Sulphur Extrusion from a meso-Thiaphlorin", J. Chem. Soc., Chem. Commun. pp. 807-809, 1970.
Broadhurst et al., "18- and 22-.pi.-Electron Macrocycles Containing Furan, Pyrrole, and Thiophen Rings", J. Chem. Soc., Chem. Commun. pp. 1480-1482, 1969.
Broadhurst et al., "New Macrocyclic Aromatic Systems Related to Porphins", J. Chem. Soc., Chem. Commun. pp. 23-24, 1969.
Broadhurst et al., "The Synthesis of 22 .pi.-Electron macrocycles. Sapphyrins and Related Compounds", J. Chem. Soc. Perkin Trans., 1;2111-2116, 1972.
Cuellar et al., "Synthesis and Characterization of Metallo and Metal-Free Octaalkylphthalocyanines and Uranyl Decaalkysuperphthalocyanines", Inorg. Chem., 20:3766-3770, 1981.
Day et al., "Large Metal Ion-Centered Template Reactions. A Uranyl Complex of Cyclopentakis (2-iminoisoindoline)", J. Am. Chem. Soc., 97:4519-4527, 1975.
De Cola et al., "Hexaaza Macrocyclic Complexes of the Lanthanides", Inorg. Chem., 25:1729-1732, 1986.
Dougherty, "Photosensitizers: Therapy and Detection of Malignant Tumors", Photochem. Photobiol., 45:879-889, (1987).
Gosmann et al., "Synthesis of a Fourfold Enlarged Porphyrin with an Extremely Large, Diamagnetic Ring-Current Effect", Angew. Chem., Int. Ed Engl., 25:1100-1101, (1986).
Gossauer, "Syntheses of Some Unusual Polypyrrole Macrocycles", Bull. Soc. Chim. Belg., 92:793-795, (1983).
Knubel et al., "Biomimetic Synthesis of an Octavinylogous Porphyrin with an Aromatic [34] Annulene System", Angew. Chem., Int. Ed. Engl., 27:1170-1172, 1988.
Lauffer, "Paramagnetic Metal Complexes as Water Proton Relaxation Agents for NMR Imaging: Theory and Design", Chem. Rev., 87:901-927, 1987.
LeGoff et al., "Synthesis of a [1,5,1,5] Platyrin, a 26 .pi.-Electron Tetrapyrrolic Annulene", J. Org. Chem., 52:710-711, 1987.
Marks et al., "Large Metal Ion-Centered Template Reactions. Chemical and Spectral Studies of the Superphthalocyanine Dioxocyclopentakis (1-iminoisoindolinato) uranium (VI) and Its Derivatives", J. Am. Chem. Soc., 100:1695-1705, 1978.
Rexhausen et al., "The Synthesis of a New 22 .pi.-Electron macrocycle: Pentaphyrin", J. chem. Soc., Chem. Commun., p. 275, 1983.
Sessler et al., "Synthesis and Crystal Structure of a Novel Tripyrrane-Containing Porphyrinogen-like Macrocycle", J. Org. Chem., 52:4394-4397, 1987.
Sessler et al., "The Coordination Chemistry of Planar Pentadentate Porphyrin-Like Ligands", Comm. Inorg. Chem., 7:333-350, 1988.
Sessler et al., "An Expanded Porphyrin: the Synthesis and Structure of a New Aromatic Pentadentate Ligand", J. Am. Chem. Soc., 110:5586-5588, 1988.
Tweedle et al., "Principles of Contrast-Enhanced MRI", in Magnetic Resonance Imaging, 2nd ed. Partain, et al, Eds., W. B. Saunders: Philadelphia, vol. I (1988) 793-809.
Vogel et al., "Porphycene--a Novel Porphin Isomer", Angew. Chem., Int. Ed. Engl., 25:257-259, 1986.
Vogel et al., "2,7,12,17-Tetrapropylporphycene-- Counterpart of Octaethyiporphyrin in the Porphycene Series", Angew. Chem., Int. Ed. Engl., 26:928-931, 1987.
Sessler et al., "A Water-Stable Gadolinium (III) Complex Derived from a New Pentadentate Expanded Porphyrin Ligand", Inorg. Chem., 28:3390-3393, 1989.
Sessler et al., "Binding of Pyridine and Benzimidazole to a Cadmium Expanded Porphyrin: Solution and X-ray Structural Studies", Inorg. Chem., 28:1333-1341, 1989.
Harriman et al., "Metallotexaphyrins: A New Family of Photosensitisers for Efficient Generation of Singlet Oxygen", J. Chem. Soc., Chem. Commun., 314-316, 1989. Submitted as A32 in 1449 for UTSB:458.
Sessler et al., "Expanded Porphyrins: The synthesis and Metal Binding Properties of Novel Tripyrran-Containing Macrocycles", J. Coord. Chem., 18:99-104, 1988.
Sessler et al., "The Synthesis and Structure of a Novel 22 .pi.-Electron Aromatic Pentadentate Macrocyclic Ligand: An Expanded Porphyrin", Toronto ACS Meeting, Jun. 1988. USA.
Sessler et al., "A Water-Stable Gadolinium (III) Complex Derived from a New Pentadentate", Chem. Absts., 111:720, abstract No. 125716e, Oct. 2, 1989.
Stinson, "Unusual Porphyrin Analog Promises Many Applications", Chemical and Engineering News, pp. 26-27, Aug. 8, 1988.
Sessler et al., "Tripyrroledimethine-derived (Texaphyrin-type) Macrocycles: Potential Photosensitizers Which Absorb in the Far-red Spectral Region", SPIE, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanism and Technique, 1426:318-329, 1991.
Sessler et al., "`Texaphyrin`: A Novel 22 .pi.-Electron Aromatic Pentadentate Macrocyclic Ligand", ACS Meeting, Los Angeles, Sep. 1988.
Sessler and Burrell, "Expanded Porphyrins," Topics in Current Chemistry, 161:180-273, 1991.
Sessler et al., "Synthesis and Structural Characterization of Lanthanide (III) Texaphyrins," Inorganic Chemistry, 32(14):3175-3187, 1993.
"2-Athylamino-2-methyl-propanol-(1)", Beilstein's Handbuch, 4:785, 1950.
"Tentative Rules for Carbohydrate Nomenclature Part 1 (1969)," Handbook of Biochemistry and Molecular Biology, 3rd ed., Fasman, Ed., CRC Press, Cleveland, Ohio pp. 100-102.
Sessler et al., "Preparation of Lanthanide (III) Texaphyrin Complexes and Their Applications to Magnetic Resonance Imaging and Photodynamic Therapy," Abstracts of Papers, Part 1, 204th ACS National Meeting, Aug. 23-28, 1992, Washington, DC.
Sessler et al., "Synthesis and Applications of Sch
Iverson Brent
Magda Darren
Sessler Jonathan L.
Board of Trustees, Univ. of TX Sys.
Larson Jacqueline S.
Pharmacyclics Inc.
Raymond Richard L.
LandOfFree
Chromophore probe for detection of nucleic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chromophore probe for detection of nucleic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chromophore probe for detection of nucleic acid will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2322355