Process for preparation of substituted-aminomethylphosphonic aci

Details Process for preparation of substituted-aminomethylphosphonic aci Process for preparation of substituted-aminomethylphosphonic aci

1987-11-20

1989-05-16

Evans, J. E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2605025D, C07F 938

Patent

active

048307882

ABSTRACT:
A process is disclosed for the preparation of N-substituted aminomethylphosphonic acids, particularly methylaminomethylphosphonic acid, in high yield and purity with related low production cost using conventional equipment, which comprises the steps of (a) reacting an N-substituted amide with paraformaldehyde in a low molecular weight carboxylic acid to form the N-methylol derivative, (b) reacting the N-methylolamide with PCl.sub.3 i n excess low molecular weight carboxylic acid and heating to form the phosphonomethyl derivative, (c) hydrolyzing acid chloride and acid anhydride with water, (d) distilling off the low-molecular weight carboxylic acid, (e) hydrolyzing the N-acyl group with water and strong acid catalyst, (f) adding low molecular weight alcohol to crystallize the N-substituted-aminomethylphosphonic acid and (g) filtering, and washing the product.

REFERENCES:
patent: 2304156 (1942-12-01), Engelmann et al.
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patent: 3288846 (1966-11-01), Irani et al.
patent: 4368162 (1983-01-01), Maier
patent: 4409151 (1983-10-01), Redmove et al.
patent: 4422982 (1983-12-01), Subramanian
patent: 4578224 (1986-03-01), Bayer et al.
Vogel "Practical Organic Chemistry" 3rd ed. (1957), pp. 131 and 132.

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