Pharmaceutical compounds, preparation, use and intermediates the

Details Pharmaceutical compounds, preparation, use and intermediates the Pharmaceutical compounds, preparation, use and intermediates the

1981-12-18

1985-08-13

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

560 53, 562463, 514815, 514520, 514381, 514605, C07C 6540

Patent

active

045351830

ABSTRACT:
This invention is directed to novel ether compounds of formula (I) ##STR1## which are of value in medicine in the palliation of haemoglobinopathies, in particular sickle-cell anemia, and also in the palliation of pulmonary dyefunction, protection from the effects of hypoxia and the radio-sensitization of tumours. The invention is also directed to methods for the preparation of the ether compounds, to pharmaceutical formulations containing them, the preparation of such formulations and the use of the compounds in human medicine. Also provided by the invention are intermediates of value in the preparation of the ether compounds, by the methods described, and the preparation of the intermediates.

REFERENCES:
patent: 3914286 (1975-10-01), Mieville
Dean, J. et al., New England Journal of Med., vol. 299, No. 14, pp. 752-763, 804-811, 863-870, (1978).

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