Certain 4-(2-hydroxyethylthiomethyl)pyridines and derivatives th

Details Certain 4-(2-hydroxyethylthiomethyl)pyridines and derivatives th Certain 4-(2-hydroxyethylthiomethyl)pyridines and derivatives th

1983-03-18

1985-08-13

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546339, 546341, 546342, 546344, C07D21332, A61K 3144

Patent

active

045350841

ABSTRACT:
A series of 4-(2-hydroxyethylthiomethyl)pyridines and related compounds, and their pharmaceutically acceptable acid addition salts, having immunoregulatory activity are disclosed. Preferred compounds include 4-(2-hydroxyethylthiomethyl)pyridine itself, as well as 4-(2-hydroxy-1-propylthiomethyl)pyridine, 4-(3-hydroxy-2-butylthiomethyl)pyridine, the acetate esters corresponding to the above compounds, and 4-(2,3-dihydroxy-1-propylthiomethyl)pyridine.

REFERENCES:
patent: 3409626 (1968-11-01), Cavallito et al.
patent: 3636074 (1972-01-01), Geering et al.
Vejdelek et al., Chemical Abstracts, 49, 336f, (1955).
T. DiPerri et al., European Journal of Rheumatology and Inflammation, vol. 1, pp. 155-164, (1978).
R. F. van Ginckel et al., Eur. J. Immunol., vol. 6, pp. 305-307, (1976).

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