Combining an anionic blocking agent with dyphylline

Details Combining an anionic blocking agent with dyphylline Combining an anionic blocking agent with dyphylline

1980-12-09

1985-08-13

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514562, A61K 31465

Patent

active

045350825

ABSTRACT:
The potential of dyphylline as a bronchodilator is severely limited by its short half-life. By administering an anionic blocker prior to or concurrently with dyphylline, this shortcoming is overcome, and effective plasma levels can be maintained for as long as eight hours.

REFERENCES:
patent: 4348397 (1982-09-01), May et al.
Goodman & Gilman-The Pharmacological Basis of Therapeutics (Textbook), 6th ed., 1980, pp. 929-932.
Cunningham, R. F., et al., "Clinical Pharmacokinetics of Probenecid", Clinical Pharmacokinetics, 6:135-151, (1981).
Simons, K. J., and Simons, F. E. R., J. Pharm. Sci., 68, 1327-1328, Oct. 1979.
Research Communications in Chemical Pathology and Pharmacology, vol. 23, No. 3, 523-531, Mar. 1979.
Giscion, L. G., Ayres, J. W. & Ewing, G. H., Am. J. Hosp. Pharm., vol. 36, 1179-1184, Sep. 1979.

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