Method of depletion of methionine in plasma and solid tumors and

Details Method of depletion of methionine in plasma and solid tumors and Method of depletion of methionine in plasma and solid tumors and

1997-02-27

2000-01-25

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

424 945, A61K 31195, A61K 3851, A61K 3852, A61K 3853

Patent

active

060179627

ABSTRACT:
The present invention provides a method of depleting methionine in the plasma of an individual in need of such treatment, comprising the steps of: administering to said individual a pharmacologically effective amount of a methionine scavenger; and treating said individual with homocystine. Also provided is a method of method of treating a methionine-dependent tumor in an individual in need of such treatment, comprising the steps of: administering to said individual a pharmacologically effective amount of a methionine synthetase inhibitor; treating said individual with homocystine while depriving dietary methionine, homocysteine and choline; and administering to said individual a pharmacologically effective amount of an anti-neoplastic alkylating agent.

REFERENCES:
Kreis, Willis; Hession, Catherine; Biological Effects of Enzylmatic Deprivation of L-Methioine in Cell Culture and an Experimental Tumor. Cancer Research 33, 1866-1869, (Aug. 1973).
Lishko, Valeryi K.; Lishko, Olga V.; Hoffman, Rovert M.; Depletion of Serum Methionine by Methioninase in Mice. AntiCancer Research 13, 14655-1468 (1993).
Breillout, T.;' Hadida, F.; Echinard-Garin, P.; Lascaux, V.; Poupon, M.-F.; Decreased Rat Rhabdomyosarcoma Pulmonary Metastases in Response to a Low Methionine Diet. AntiCancer Research 7, 861-868 (1987).
Narihide Goseki, MD.; Sigeru Yalmazaki, MD.; Mitsuo Endo, MD.; Tokio Onodera, MD.; Goro Kosaki, MD.; Yutaka Hibino, Mse; Tokuo Kuwahata, BSPharm; Antitumor Effect of Methionine-Depleting Total Parenteral Nutrition With Doxorubicin Administration on Yoshida Sarcoma-Bearing Rats. Cancer &, 1865-1872 (Apr. 1, 1992).
Lishko, Valeryi K.; Lishko, Olga V.; Hoffman, Rovert M.; Depletion of Serum Methionine by Methioninase in Mice. AntiCancer Research 13, 14655-1468 (1993).

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