Phenyl glycine compounds and methods of treating atherosclerosis

Details Phenyl glycine compounds and methods of treating atherosclerosis Phenyl glycine compounds and methods of treating atherosclerosis

1999-07-26

2000-01-25

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

562445, 562446, 564165, 544171, 544399, 546264, 546312, 546335, 548569, 549 77, 549438, 549439, 549494, 558414, 560 21, 560 39, 560 40, A61K 31215, A61K 31535, C07D29515

Patent

active

06017918&

ABSTRACT:
The present invention provides compounds having the Formula I ##STR1## The present invention also provides methods of treating atherosclerosis, coronary heart disease, and restenosis using the compounds of Formula I, and pharmaceutical compositions comprising the compounds of Formula I.

REFERENCES:
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patent: 5234939 (1993-08-01), Capiris et al.
patent: 5489611 (1996-02-01), Lee et al.
patent: 5491172 (1996-02-01), Lee et al.
Senuma et al, Chemical Abstracts, vol. 91, No. 57538, 1979.
Isomura, et a., Chem. Pharm. Bull., "Synthesis and Anti-inflammatory Activity of 2,6-Di-tert-butylphenols with a Heterocyclic Group at the 4-Z Position. III", 1984, vol. 32:1, pp. 152-165.
Lazer, et al., J. Med. Chem., "Antinnflammatory 2,6-Di-tert-butyl-4-(2-arylethenyl)phenos", 1989, vol. 32, pp. 100-104.

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