Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-02-02
1988-03-08
Brust, Joseph Paul
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548181, 548214, 548233, 548245, 548246, 548336, 548467, 548486, A61K 3140, C07D20934
Patent
active
047300043
ABSTRACT:
Certain new 2-oxindole-3-carboxamide compounds having an acyl substituent at the 1-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and anti-inflammatory agents in mammalian subjects. In particular, the compounds of the invention are useful for acute administration for ameliorating or eliminating pain in human subjects recovering from surgery or trauma, and also for chronic administration for alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis, in human subjects.
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patent: 3632587 (1972-01-01), Hollowood
patent: 3634453 (1972-01-01), McManus et al.
patent: 4569942 (1986-02-01), Kadin
Tacconi, et al., Tetrahedron, 27, (1971) pp. 561-579.
C.A., 51:5044a (1957), Kisteneva.
Akers Lawrence C.
Brust Joseph Paul
Lumb J. Trevor
Pfizer Inc.
Richardson Peter C.
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