Mixed micellar delivery system and method of preparation

Details Mixed micellar delivery system and method of preparation Mixed micellar delivery system and method of preparation

1998-02-10

2000-01-25

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

424433, 424455, 514946, 514947, 514 2, A61K 900, A61K 966, A61F 1300

Patent

active

060175451

ABSTRACT:
A mixed micellar pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, alkali metal salicylate, a pharmaceutically acceptable edetate and at least one absorption enhancing compounds. The absorption enhancing compounds are selected from the group consisting of lecithin, hyaluronic acid, pharmaceutically acceptable salts of hyaluronic acid, octylphenoxypolyethoxyethanol, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linolenic acid, borage oil, evening of primrose oil, trihydroxy oxo cholanylglycine, glycerin, polyglycerin, lysine, polylysine, triolein and mixtures thereof. The amount of each absorption enhancing compound is present in a concentration of from 1 to 10 wt./wt. % of the total formulation, and the total concentration of absorption enhancing compounds are less than 50 wt./wt. % of the formulation.

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