Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-07-17
1993-07-13
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548495, 514 12, C07D20912, A61K 31415
Patent
active
052273970
ABSTRACT:
This invention relates to certain polyamines and polypeptides found to be present in the venom of the Agelenopsis aperta spider. The polyamines of this invention and the salts thereof antagonize excitatory amino acid neurotransmitters, which neurotransmitters affect cells of various organisms and are useful in antagonizing said neurotransmitters, per se, in the treatment of excitatory amino acid neurotransmitter mediated diseases and conditions and in the control of invertebrate pests. The polypeptides of this invention and one of said polyamines and the salts thereof block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se, in the treatment of calcium channel mediated diseases and conditions and in the control of invertebrate pests. This invention also relates to compositions comprising said polyamines, polypeptides and salts thereof.
REFERENCES:
patent: 4925664 (1990-05-01), Jackson et al.
patent: 4950739 (1990-08-01), Cherksey et al.
patent: 5037846 (1991-08-01), Saccomano et al.
Wayne S. Skinner, et al., "Purification and Characterization of Two Classes of Neurotoxins from the Funnel Web Spider, Agelenopsis aperta", J. Biol. Chem. 264:2150-2155 (1989).
H. Jackson, et al., "Spider toxins as tools for dissecting elements of excitatory amino acid transmission", Trends in Neuroscience 11:278-283 (1988).
B. Cherksey et al., "Isolation of a voltage dependent calcium channel from the squid nervous system", Biophys, J. 55:438a (1989).
V. P. Bindokas, et al., ".omega.-AGAI, A Spider Venom Toxin from Agelenopsis aperta, Irreversibly Blocks Transmitter Release at Insect and Frog Neuromuscular Junctions", Soc. Neuroscience Abstracts 14:30 (No. 17.11) (1988).
M. E. Adams, et al., "Spider Venom Toxins Acting on Three Classes of Synaptic Ion Channels at the Insect Neuromuscular Junction", Soc. Neuroscience Abstracts 14:30 (No. 17.10) (1988).
M. Sugimori, et al., "Spider Venom Blockade of Dendritic Calcium Spiking in Purkinje Cells Studied In Vitro", Soc. Neuroscience Abstracts 13:228 (No. 69.1) (1987).
H. Jackson, et al., "Suppression of Chemically-Induced Behavioral Seizures in Rats by a Novel Spider Toxin", Soc. Neuroscience Abstracts 13:1078 (No. 300.6) (1987).
H. Jackson, et al., "Presynaptic Blockade of Transmission by a Potent, Long-Lasting Toxin from Agelenopsis aperta Spiders", Soc. Neuroscience Abstracts 12:730 (No. 197.4) (1986).
L. M. Kerr, et al., "Effects of Spider Toxins and L and N CNS Calcium Channels: Inhibition and Enhancement of Binding", Soc. Neuroscience Abstracts 13:102 (No. 31.15) (1987).
J. Hollis, et al., "Effects of Spider Venom on Vertebrate CNS Glutamate Binding", Soc. Neuroscience Abstracts 13:756 (No. 209.3) (1987).
H. Jackson, et al., "Spider Venoms Block Synaptic Transmission Mediated by Non-N-methyl-D-aspartate Receptors in the Avian Cochlear Nucleus", Soc. Neuroscience Abstracts 11:107 (No. 32.17) (1985).
R. Llinas, et al., "Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison", PNAS 86:1689-1693 (1989).
Nerotox '88 Molecular Basis of Drug & Pesticide Action, G. G. Lunt, Ed., Excerpta Medica, Amsterdam-New York-Oxford, 1988, Chapter 4, pp. 49-59.
V. P. Bindokas, et al., ".omega.-Aga-I: A Presynaptic Calcium Channel Antagonist from Venom of the Funnel Web Spider, Agelenopsis aperta," J. Neurobiology 20:171-188 (1989).
B. C. Albensi, et al., "Effects of Calcium Antagonist Peptide Spider Toxins on Hippocampal Synaptic Transmission Studied In Vitro," Soc. Neurosci, Abstr., 15:652 (No. 373.11) (1989).
L. D. Artman, et al., "Peptide Toxins from Agelenopsis aperta Spider Venom Block Depolarization-Induced Increases in Cytosolic Free Calcium in Rat Cerebellar Granule Neurons", Soc. Neurosci. Abstr. 15:356 (No. 147.17) (1989).
V. P. Bindokas, et al., "Are Two Sub-Types of Presynaptic Calcium Channels Involved in Neurotransmitter Release at the Insect Neuromuscular Junction?" Soc. Neurosci. Abstr. 15:26 (No. 16.6) (1989).
J. M. Pocock, et al., "Effects of .omega.-Agatoxins on Voltage-Department Ca.sup.++ Flux in Chick Brain Synaptosomes", Soc. Neurosci. Abstr. 15:652 (No. 264.7) (1989).
M. E. Adams, et al., ".omega.-Agatoxins: A Family of Neuronal Ca.sup.++ Channel Antagonists from Funnel Web Spider (Agelenopsis aperta) Venom", Soc. Neurosci. Abstr. 15:652 (No. 264.6) (1989).
J. W. Lin, et al., "A Funnel-Web Spider Toxin (FTX) Fraction Blocks Calcium Currents Induced by Rat Brain mRNA in Xenopus Oocytes", Soc. Neurosci. Abstr. 15:652 (No. 264.9) (1989).
T. N. Parks, et al., "Polyamine Spider Toxins Block NMDA Receptor-Mediated Increases in Cytosolic Calcium in Cerebellar Granule Neurons", Soc. Neurosci. Abstr. 15:1169 (No. 463.25) (1989).
M. E. Adams, et al., ".omega.-Agatoxins: Novel Calcium Channel Antagonists of Two Subtypes from Funnel Web Spider (Agelenopsis aperta) Venom", J. Biol. Chem. 265:861-867 (1990).
A. L. Mueller, et al., "Effects of Polyamine Spider Toxins on NMDA Receptor-Mediated Transmission in Rat Hippocampus In Vitro", Soc. Neurosci. Abstr. 15:945 (No. 373.10) (1989).
A. L. Mueller, et al., "Polyamine Spider Toxins as Novel NMDA Receptor Antagonists", Symposium-The Neurobiology of the NMDA Receptor: From Chemistry to Clinic, Pittsburgh, Pa., Oct. 27-28, 1989.
T. Chaudhary, et al., "Use of .sup.252 Cf Plasma Desorption and Laser Desorption MS to Elucidate an Unexpected Modification of a Neurotoxic Protein", 38th ASMS Conference on MS and Allied Topics, Tucson, Ariz., Jun. 3-8, 1990.
H. Jackson, et al., "Effects of Spider Venoms on Transmission Mediated by Non-N-Methyl-D-Aspartate Receptors in the Avian Cochlear Nucleus", Excitatory Amino Acid Transmission, pp. 51-54 (1987).
Saccomano Nicholas A.
Volkmann Robert A.
Benson Gregg C.
McFarlin D. Stuart
Pfizer Inc.
Richardson Peter C.
Springer David B.
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