Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-06-10
1993-07-13
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514294, 540581, 546 79, A61K 31435, A61K 31395, C07D47118, C07D48718
Patent
active
052273776
ABSTRACT:
The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT.sub.3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT.sub.3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
REFERENCES:
patent: 4273778 (1981-06-01), Hadley et al.
patent: 4336259 (1982-06-01), Hadley et al.
patent: 4472413 (1984-09-01), Hadley et al.
patent: 4797387 (1989-01-01), King
patent: 4797406 (1989-01-01), Richardson et al.
patent: 4816453 (1989-03-01), Watts
Fludzinski et al., Inazoles as Indole Bioesters, J. Med. Chem., 30, No. 9, 1535-7, Apr. 1987.
Flynn Daniel L.
Nosal Roger
Dentz Bernard
G. D. Searle & Co.
Kovacevic Cynthia S.
Matukaitis Paul D.
Williams Roger A.
LandOfFree
Meso-azacyclic amides of certain bicyclic carboxylic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Meso-azacyclic amides of certain bicyclic carboxylic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Meso-azacyclic amides of certain bicyclic carboxylic acids will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2312164