Process for the isolation and purification of ester functionaliz

Details Process for the isolation and purification of ester functionaliz Process for the isolation and purification of ester functionaliz

1994-09-19

1996-04-23

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23390, C07D23368

Patent

active

055104959

ABSTRACT:
A method for isolating and purifying an ester functionalized imidazole compound, useful as an angiotensin (II) antagonist or as a key intermediate therefor, from a mixture of it with its regioisomer in a solvent, by treatment with an alkali metal hydroxide to achieve the regioselective hydrolysis of the undesired regioisomeric ester.

REFERENCES:
patent: 5310929 (1994-05-01), Ardecky et al.
patent: 5312828 (1994-05-01), Finkelstein et al.
patent: 5338740 (1994-08-01), Carpino et al.
Adams et al, "Organic Reactions", vol. II, Chapt. 9, pp. 376 to 404 (1944).
Starks et al, "Phase Transfer Catalysts", Chapt. 9, pp. 337 to 343 (1978).

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