Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1983-04-29
1986-03-18
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514 83, 514 85, 514 89, 514 90, 514 91, 514 92, 546 22, 544108, 544157, 544159, 544404, 548112, 260239E, 558172, A61K 3142, A61K 31425, A61K 3144, A61K 31685
Patent
active
045769338
ABSTRACT:
Glycerol derivatives, inclusive of salts thereof, of the formula ##STR1## wherein R.sup.1 is alkyl or alkylcarbamoyl containing 10 to 30 carbon atoms, R.sup.2 and R.sup.3 are independently hydrogen, C.sub.1-6 alkyl or, taken together with the adjacent nitrogen atom, form cyclic amino, and ##STR2## represents cyclic ammonio, and of the formula ##STR3## wherein R.sup.1 is as defined above, R.sup.2' and R.sup.3' are C.sub.1-6 alkyl or, taken together with the adjacent nitrogen atom, form cyclic amino and R.sup.4', R.sup.5' and R.sup.6' are independently hydrogen or C.sub.1-6 alkyl, are useful as antihypertensive agents.
REFERENCES:
Central Patents Index Basic Abstracts Journal, Section B: Farmdoc, 12005C/07 B05 Toya 22.06.78 J55002-636 (Apr. 9, 1980).
Biochemical and Biophysical Research Communications, vol. 90, pp. 1194-1200 (1979).
Hypertention, vol. 3, (Supp I), p. I-107-I-111, (1981).
Rinshokagaku (The Journal of Clinical Science), vol. 17, pp. 1462-1467 (1981).
Nishikawa Kohei
Tsushima Susumu
Rotman Alan L.
Takeda Chemical Industries Ltd.
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