Method of use of 1-(alkyl for alkylcarbanoyl)-2-carbamoylglycero

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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514 83, 514 85, 514 89, 514 90, 514 91, 514 92, 546 22, 544108, 544157, 544159, 544404, 548112, 260239E, 558172, A61K 3142, A61K 31425, A61K 3144, A61K 31685

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045769338

ABSTRACT:
Glycerol derivatives, inclusive of salts thereof, of the formula ##STR1## wherein R.sup.1 is alkyl or alkylcarbamoyl containing 10 to 30 carbon atoms, R.sup.2 and R.sup.3 are independently hydrogen, C.sub.1-6 alkyl or, taken together with the adjacent nitrogen atom, form cyclic amino, and ##STR2## represents cyclic ammonio, and of the formula ##STR3## wherein R.sup.1 is as defined above, R.sup.2' and R.sup.3' are C.sub.1-6 alkyl or, taken together with the adjacent nitrogen atom, form cyclic amino and R.sup.4', R.sup.5' and R.sup.6' are independently hydrogen or C.sub.1-6 alkyl, are useful as antihypertensive agents.

REFERENCES:
Central Patents Index Basic Abstracts Journal, Section B: Farmdoc, 12005C/07 B05 Toya 22.06.78 J55002-636 (Apr. 9, 1980).
Biochemical and Biophysical Research Communications, vol. 90, pp. 1194-1200 (1979).
Hypertention, vol. 3, (Supp I), p. I-107-I-111, (1981).
Rinshokagaku (The Journal of Clinical Science), vol. 17, pp. 1462-1467 (1981).

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