Fixed tissue medical devices comprising albumin-binding dyes

Details Fixed tissue medical devices comprising albumin-binding dyes Fixed tissue medical devices comprising albumin-binding dyes

1993-04-08

1996-04-23

Prebilic, Paul B.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

623 2, 604266, A61F 202

Patent

active

055099327

ABSTRACT:
An implantable medical device is provided which comprises a fixed tissue incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a physiological fluid containing albumin. These albumin-binding dyes have been found to significantly reduce calcification when incorporated in tissue heart valves. A method of increasing the albumin-binding ability of an implantable medical device is also provided.

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