Peptides, their preparation and compositions containing them

Details Peptides, their preparation and compositions containing them Peptides, their preparation and compositions containing them

1980-06-27

1990-04-10

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, 530331, 530332, C07K 508, C07K 510, C07K 3702

Patent

active

049161199

ABSTRACT:
Tripeptides of the general formula: ##STR1## wherein the symbols R, which may be the same or different represent hydrogen or a fatty acid residue (at least one of them representing a fatty acid residue), R.sub.1 represents hydroxy, amino or alkoxy and R.sub.2 and R.sub.3, which may be the same or different, represent hydrogen, carboxy, carbamoyl or alkoxycarbonyl radical (with the proviso that R.sub.2 and R.sub.3 cannot simultaneously represent a hydrogen atom), the alanine moiety being in the L form, the glutamic acid moiety being in the D form, the lysine moiety (when R.sub.2 or R.sub.3 =a hydrogen atom) being in the L form and the 2,6-diaminopimelic acid moiety or its derivatives (when R.sub.2 and/or R.sub.3 =carboxy, carbamoyl or alkoxycarbonyl) being in the D,D, L,L, D,D/L,L (racemic) or D,L (meso) form, and salts thereof, possess immunological adjuvant and immunostimulant activity.

REFERENCES:
patent: 4311640 (1982-01-01), Kuroda et al.
Life Sciences, vol. 26, pp. 883-888, Jan. 17, 1980.
C. R. Acad. Se. Paris, 1.289, (Sep. 24, 1979).
Comptes Rendus Hebdomandaires Des Seames De L'Academie Des Sciences Paris, pp. 1320-1304, (1965).
Bulletin de la Societe de Chimie Biologigie, 1967, 49, No. 11, pp. 1579-1591.
Agricultural and Biological Chemistry, 41,(5), 763-768, 1977.
11th Internat'l Congress of Chemotherapy 19th Interscience Conference on Antimicrobial Agents & Chemitherapy, (1979).
Biochem- and Biophys. Res. Commun. 59, 1974, 1317-1325.
Biochemistry, vol. 9, No. 4, 1970, 823-831.

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