Hypoglycemic 5-pyrrolyl, indolyl and quinolyl substituted oxazol

Details Hypoglycemic 5-pyrrolyl, indolyl and quinolyl substituted oxazol Hypoglycemic 5-pyrrolyl, indolyl and quinolyl substituted oxazol

1984-01-26

1986-01-21

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514422, 546175, 546275, 546280, 546329, 548165, 548213, 548227, 549398, 549462, A61K 3140, A61K 3147, C07D41102, C07D41304

Patent

active

045658200

ABSTRACT:
Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]-furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.

REFERENCES:
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patent: 3699229 (1972-10-01), Plotnikoff
patent: 3899533 (1975-08-01), Souchard
patent: 4220787 (1980-09-01), Scholz
Blank et al, J. Org. Chem., 26, pp. 1551-1553, (1961).
Barthel et al., J. Org. Chem. 19, pp. 485-489, (1954).
Dostert et al., Eur. J. Med. Chem.--Chimica Therapeutica 15, pp. 199-205, (1980).
Ciamacian and Silber, Ber. 19, pp. 1708-1717, (1886).
Clark-Lewis, Chem. Rev. 58, pp. 63-99, (1958).
Brink and Freeman, J. Neuro. Chem. 19 (7), pp. 1783-1788, (1972).

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