Pharmaceutically active triazolopyridine compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546117, A61K 31435, C07D47104

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active

052409376

ABSTRACT:
This invention describes the preparation and use of anticonvulsant agents. In particular, triazolopyridine compounds are described which have utility in the treatment of epilepsy in mammals.

REFERENCES:
patent: 5166209 (1992-11-01), Kelley
J. L. Kelley, et al., J. of Het. Chem., Jul.-Aug., 1986, pp. 1189-1193, vol. 23, Synthesis of 9-(2-Fluorobenzyl)-6-methylamino-9H-purine.
J. L. Kelley, et al., J. of Medicinal Chemistry pp. 1133-1134, 9-(2-Fluorobenzyl)-6-(methylamino) 9H-purine Hydrochloride. Synthesis and Anticonvulsant Activity (1986).
J. L. Kelley, et al., Journal of Medicinal Chemistry, 1988, vol. 31, No. 5, pp. 1005-1009, 9-(2-Fluorobenzyl)-6-(alkylamino)9H-purines. A New Class of Anticonvulsant Agents.
Woodbury, et al., Arch. int. pharmacodyn., 1952, XCII, No. 1, pp. 97-107 Design and Use of a New Electroshock Seizure Apparatus and Analysis of Factors Altering Seizure Threshold and Pattern (1).
Houston, et al., J. Med. Chem., 1985, 28, pp. 467-471, Potential Inhibitors of S-Adenosylmethionine-Dependent Methyltransferases. 8. Molecular Dissections of Carbocyclic 3-Deazaadenosine as Inhibitors of S-Adenosyl-homocystein Hydrolasse.
Chemical Abstracts CA52:9072D--B. W. Ashton and H. Suschitsky--carbazole synthesis of certain triazoles, none of which are encompassed by the general formula (1957).
J. L. Kelley, et al., J. of Het. Chemistry Jul.-Aug., 1988, pp. 1255-1258, vol. 25, Synthesis and Anticonvulsant Activity of 1-Benzyl-4-alkylamino-1H-imidazo [4,5-c]pyridines.
J. L. Kelley, et al., Journal of Medicinal Chemistry, 1988, vol. 31, No. 3, pp. 606-612, 6-(Alkylamino)9-H-purines. A New Class of Anticonvulsant Agents.

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