Single sample method for determination of lipoprotein concentrat

Details Single sample method for determination of lipoprotein concentrat Single sample method for determination of lipoprotein concentrat

1975-10-10

1977-08-02

Scovronek, Joseph

Chemistry: physical processes

Physical processes

Crystallization

252408, G01N 3316

Patent

active

040392856

ABSTRACT:
A single-sample method for determining concentrations of individual lipoprotein classes and lipids in blood by turbidimetric measurement. The blood serum is mixed with an ionic-strength-sensitive agent for forming an insoluble complex with the chylomicron, very low density, and low density lipoprotein classes, and the ionic strength of the mixture is raised in steps to cause progressive dissolution of each class of complex from that of highest density lipoprotein to that of lowest density lipoprotein. Measurement of the turbidity due to the insoluble complex(es) present at each step allows calculation of the turbidity due to the complex of each individual lipoprotein class and from that the concentration of each lipoprotein class and lipid in the blood sample.

REFERENCES:
patent: 3436187 (1969-04-01), Ferro et al.
patent: 3479154 (1969-11-01), Cardinal
patent: 3558516 (1971-01-01), Wybenga
patent: 3791791 (1974-02-01), Finkel et al.
Scholnick et al. "Protides of the Biological Fluids, Proceedings of the 19th Coloquiuum 1971", H. Peeters, Ed. pp. 289-292.
Searcy et al. "A Screening Procedure for Detecting and Characterizing Hyperlipoproteinemia", Clinica Chimica Acta, 38 (1972) 291-300.
Stone et al. "A New Technique for the Investigation of the Low-Density Lipoproteins in Health and Disease", Clinica Chimica Acta, 14 (1966) 812-830.
Stone et al. "Diagnosis and Classification of Abnormal Lipoprotein Patterns", Clinica Chimica Acta, 31 (1971) 333-354.

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