Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1992-01-29
1993-08-31
Rollins, John W.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
514 56, 604 52, 604 53, A61K 31745, A61K 31725, A61M 3100
Patent
active
052407012
ABSTRACT:
In accordance with the present invention, a method is provided for improving angioplasty procedures by reducing tissue damage during the procedure comprising infusing a non-emulsion, homogeneous solution of certain ethylene oxide-propylene oxide surface-active copolymers before, during and/or after the angioplasty procedure. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula:
REFERENCES:
patent: Re29909 (1979-02-01), Kutz
patent: 2674619 (1954-04-01), Lundsted
patent: 2854378 (1958-09-01), Buckwalter et al.
patent: 3089818 (1963-05-01), Stone
patent: 3140232 (1964-07-01), Noseworthy
patent: 3450502 (1970-06-01), Hymes
patent: 3577522 (1971-05-01), Hymes
patent: 3590125 (1971-06-01), Hymes
patent: 3641240 (1972-02-01), Hymes et al.
patent: 3740421 (1973-06-01), Schmolka
patent: 3867521 (1975-02-01), Miskel et al.
patent: 3956259 (1976-05-01), Garcia et al.
patent: 3980772 (1976-09-01), Ginger et al.
patent: 4073886 (1978-02-01), Kehm
patent: 4100271 (1978-07-01), Kreszanoski
patent: 4179337 (1979-12-01), Davis et al.
patent: 4186253 (1980-01-01), Yokoyama et al.
patent: 4305922 (1981-12-01), Rhodes
patent: 4395393 (1983-07-01), Schmolka
patent: 4407790 (1983-10-01), Oakes et al.
patent: 4600652 (1986-07-01), Solomon et al.
patent: 4609546 (1986-09-01), Hiratani
patent: 4801452 (1989-01-01), Hunter et al.
patent: 5017370 (1991-05-01), Hunter
Schmolka, I., "A Review of Block Polymer Surfactants," Journal of the American Oil Chemists Society, 54, No. 3, pp. 110-116 (1977).
Block and Graft Copolymerization, vol. 2, (ed. by R. J. Ceresa, John Wiley & Sons, 1976) "The Applications of Block Copolymer Polyol Surfactants," L. G. Lundsted and I. R. Schmolka; pp. 174-205 and pp. 255-272 (references).
Reindorf, C. A. et al., "Perfluorocarbon Compounds: Effects on the Rheological Properties of Sickle Erythrocytes in vitro," American Journal of Hematology, vol. 19, pp. 229-236 (1985).
Padilla, F. et al., "Effect of Fluorocarbon emulsions on the mechanical fragility of normal and sickle cells: in vitro studies," Federation Proceedings, vol. 34, pp. 1510-1512 (1975).
Vercellotti, G. M. et al., "Activation of Plasma Complement by Perfluorocarbon Artificial Blood: Probable Mechanism of Adverse Pulmonary Reactions in Treated Patients and Rationale for Corticosteroid Prophylaxis," Blood, vol. 59, pp. 1299-1304 (1982).
Rodeheaver, G. T., "Pluronic.RTM. F-68: A Promising New Skin Wound Cleanser," Ann Emerg Med., 9:11, pp. 572-576 (1980).
Janoff, A. S. et al., "The Modification of Human Erythrocyte Membrane Structure by Membrane Stabilizers: An Electron Spin Resonance Study," American Journal of Hematology, vol. 10, pp. 171-179 (1981).
Moore, A. R. et al., "Reduction of Splenic Vascular Resistance During Profusion by Pluronic.RTM. F-68," Journal of Surgical Research, vol. 8, pp. 563-566 (1968).
Benner, K. U. et al., "Cold-Induced Platelet Aggregation in Vivo and Its Inhibition by a Nonionic Surface Active Substance," Thrombosis Research, vol. 2, pp. 331-342 (1973).
Hymes, A. C. et al., "The Influence of an Industrial Pluronic.RTM. F-68, In the Treatment of Hemorrhagic Shock," Journal of Surgical Research, vol. 11, pp. 191-197 (1971).
Hoie, J. et al., "Effects of Pluronic.RTM. F68, Poloxalkol, On Vascular Resistance in Vivo," Journal of Surgical Research, vol. 11, pp. 515-517, (1971).
Grover, F. L. et al., "A Nonionic Surfactant and Blood Viscosity," Arch. Surg., vol. 106, pp. 307-310 (1973).
Grover, F. L. et al., "The Effect of Pluronic.RTM. F-68 On Circulatory Dynamics and Renal and Carotid Artery Flow During Hermorragic Shock,"Journal of Surgical Research, vol. 17, pp. 30-35 (1974).
Ketchum, L. D. et al., "Experimental Use of Pluronic.RTM. F-68 In Microvascular Surgery," Plastic and Reconstructive Surgery, vol. 53, pp. 288-292 (1974).
Ketchum, L. D., "Pharmacological alterations in the clotting mechanism: Use in microvascular surgery," Journal of Hand Surgery, vol. 3, pp. 407-415 (1978).
Vasco, K. A. et al., "Poloxalkol.RTM. (Pluronic F-68): A priming solution for cardiopulmonary bypass," Trans. Am. Soc. Artif. Int. Organs, 18, pp. 526-531 (1972).
Block, N. L. et al., "Acutely traumatized canine ureter, Effects of low molecular weight dextran and surfactant Pluronic F-68," Urology, vol. III, pp. 190-194 (1974).
Knize, D. M. et al., "Use of antisludging agents in experimental cold injuries," Surgery, Gynecology & Obsterics, vol. 129, pp. 1019-1026 (1969).
Organ Perfusion and Preservation, (ed. by Norman, J. C., Appleton-Century-Crofts, (1968)), Paton, B. C. et al., "The use of a nonionic detergent added to organ perfusates," pp. 105-120.
Smillie, J. A. et al., "Cryopreservation of Human Platelets with Polyvinylpyrrolidone," Transfusion, vol. 21, pp. 552-556, (1981).
Gaehtgens, P. et al., "Desaggregation of Human Red Blood Cells by Various Surface-Active Agents as Related to Changes of Cell shape and Hemolysis," Act Heamat., vol. 33, pp. 82-89 (1975).
Advances in Blood Substitute Research (ed. by Bolin et al., Alan R. Liss, Inc. New York, (1983)), Sugi et al., "The use of Fluosol-DA (FDA) in emergency situations: a report of 67 clinical cases," Abstract/451.
Lane, T. A. et al., "Reduction in the toxicity of a component of an artificial blood substitute by supercritical fluid fractionation," Transfusion, vol. 28, pp. 375-378 (1987).
Lane, T. A. et al., "Paralysis of phagocyte migration due to an artificial blood substitute," Blood, vol. 64, pp. 400-405 (1984).
Spiess, B. D. et al., "Protection from cerebral air emboli with perfluorocarbons in rabbits," Stroke, vol. 17, pp. 1146-1149 (1986).
Kanter, K. R. et al., "Superiority of perfluorocarbon cardioplegia over blood or crystalloid cardioplegia," Circulation, vol. 64, pp. II-75-II-80 (1981).
Harjula, A. et al., "Perfluorocarbon solution as a myocardial preservative," J. Applied Cardiology, vol. 2, pp. 121-136 (1987).
Tokioka, M. D. et al., "Effects of intracoronary infusion of arterial blood or Fluosol-DA 20% on regional myocardial metabolism and function during brief coronary artery occlusions," Laboratory Investigation, vol. 75, pp. 473-481 (1987).
Benner, K. U. et al., "Uber die Wirkung von Pluronic.RTM. F68, einem polyoxypropylene-Polyoxyathylen-Kondensat, auf die ADP-induzierte Thrombocytenaggregation in vitro," Pflugers Arch., vol. 315, pp. 45-42 (1970).
Forman, M. B. et al., "Reduction of infarct size with intracoronary perfluorochemical in a canine preparation of reperfusion," Circulation, vol. 71, pp. 1060-1068 (1985).
Forman, M. B. et al., "Beneficial long-term effect of intracoronary perfluorochemical on infarct size and ventricular function in a canine reperfusion model," J. Am. Col. of Cardiol., pp. 1082-1090 (May, 1987).
Goodman, R. L. et al., "Perfluorocarbon emulsions in cancer therapy: preliminary observations on presently available formulations," Int. J. Radiation Oncology Biol. Phys., vol. 10, pp. 1421-1424 (-984).
Heron, M. W. et al., "A Method for Measuring a Nonionic Surface-Active Agent (Pluronic F-68) in Biological Fluids," Analytical Biochemistry, vol. 24, pp. 491-495 (1968).
Uno, T. et al., "Determination of Surface-Active Agents. VIII. Infrared Determination of the Proportion of Ethylene Oxide and Propylene Oxide in Pluronic," Chem. Pharm. Bull., vol. 15(1), pp. 77-82 (1967).
Hymes, A. C. et al., "Influence of an industrial surfactant (Pluronic F-68) on human amniotic fluid embolism," American Journal Obstetrics and Gynecology, vol. 107(8), pp. 1217-1222 (Aug. 15, 1970).
Grover, F. L. et al., "Beneficial Effect of Pluronic F-68 on the Microcirculation in Experimental Hemorrhagic Shock," Surgical Forum, vol. 21, pp. 30-32 (1970).
Maugh, T. H., "Perfluorochemical Emulsions: Promising Blood Substitutes," Science, vol. 179, pp. 669-672 (Feb. 1973).
Justice, C. et al., "Prevention of Thrombosis with Agents which Reduce Platelet Adhesiveness," The American Surgeon, vol. 40, pp. 186-189 (Mar. 1974).
Danielson, G. et al., "Use of Pluronic F-68 to Diminish Fat Emboli and Hemolysis During Cardiopulmonary Bypass," The Journal of Thoracic and Cardiovascular Surg
Duncan Alexander
Hunter Robert L.
Emory University
Rollins John W.
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