Renin inhibitors, processes for preparing them, methods for usin

Details Renin inhibitors, processes for preparing them, methods for usin Renin inhibitors, processes for preparing them, methods for usin

1991-03-27

1992-11-10

Cashion, Jr., Merrell C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

562430, 548542, 544383, C07D26530, C07C31500

Patent

active

051625270

ABSTRACT:
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, novel intermediates useful in the preparation thereof, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

REFERENCES:
Burger, "Medicinal Chemistry", Second edition, pp. 565-571, 573-581, 600-601 (1960).
Denkewalter et al., "Progress in Drug Research", vol. 10, pp. 510-512 (1966).
Bolis et al., "Renin Inhibitors. Dipeptide Analogues . . . " J. Med. Chem. 1987, 30, 1729-1737.
Haber et al., "Renin Inhibitors: A Search for Principles of Design", J. Card. Pharm., 10 (Suppl. 7):54-58, 1987.
Plattner et al., "Renin Inhibitors. Dipeptide Analogues . . . " J. Med Chem. 1988, 31, 2277-2288.

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