Treatment of cystic fibrosis

Details Treatment of cystic fibrosis Treatment of cystic fibrosis

1990-05-24

1992-11-10

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3141

Patent

active

051623480

ABSTRACT:
There is provided a novel therapeutic product for use in the symptomatic treatment of cystic fibrosis and for use in the manufacture of a medicament for the treatment of cystic fibrosis, as well as a method for treatment of cystic fibrosis with the therapeutic product and a method of treatment of cystic fibrosis with the therapeutic product in combination with one or more other agents indicated for the treatment of cystic fibrosis.

REFERENCES:
Berger, et al., Complement Receptor Expression on Neutrophils at an Inflammatory Site, the Pseudomonas-infected Lung in Cystic Fibrosis, J. Clin Invest. (1989), 84, 1302-1313.
Sommerhoff, C. P. et al., Neutrophil Elastase and Cathepsin G. Stimulate Secretion from Cultured Bovine Airway Gland Serous Cells, J. Clin. Invest. (1990), 85, 682-689.
Sommerhoff, C. E. et al. Neutrophil Proteases Stimulate Secretion of .sup.35 S-labeled Glycoconjugates from Cultured Bovine Tracheal Gland Serous Cells, Faseb J. (1989) 3, A534, Abstract 1791.
Suter, S., The Imbalance Between Granulocyte Neutral Proteases and Antiproteases in Bronchial Secretions from Patients with Cystic Fibrosis; In Hoiby N, Pedersen SS, Shand GH, Doring G, Holder IA (eds): Pseudomonas aeruginosa Infection. Antibiot Chemother. Basel, Karger, 1989, vol. 42. pp. 158-168.

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