Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-08-20
1992-11-10
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546321, 546283, 546194, 544 60, 544124, 544360, 514343, 514318, 514218, 5142355, 5142278, C07D21186, A61K 31455
Patent
active
051623455
ABSTRACT:
Compounds are described of the formula: ##STR1## and physiologically acceptable salts thereof, in which R.sub.1 -R.sub.7 are defined hereinafter.
The compounds represented by formula (I) reduce intracellular calcium ion concentration by limiting transmembranal calcium ion concentration and thus may be useful for the treatment of cardiovascular disorders such as hypertension.
REFERENCES:
patent: 3923818 (1975-12-01), Bossert et al.
patent: 4307103 (1981-12-01), Sato et al.
patent: 4430333 (1984-02-01), Campbell et al.
patent: 4492703 (1985-01-01), Goldmann et al.
patent: 4801599 (1989-01-01), Semeraro et al.
patent: 4806533 (1989-02-01), Semeraro et al.
Rahwan Annual Reports in Medicinal Chem. 16, 1981, p. 257.
Thomas, G. et al., J. Cardiovascular Pharm. 6, pp. 1170-1176 (1984).
Borthwick Alan D.
Gaviraghi Giovanni
Micheli Dino
Pieraccioli Daniele
Semeraro Claudio
Fan Jane T.
Glaxo S.p.A.
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