Pyrimidinedione derivatives, their production and use

Details Pyrimidinedione derivatives, their production and use Pyrimidinedione derivatives, their production and use

1991-02-13

1992-11-10

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 86, 5142358, 514253, 544123, 544243, 544295, 544300, 544309, 544310, 544311, 544312, 544313, 544314, A61K 31505, C07D23902

Patent

active

051623269

ABSTRACT:
Novel pyrimidinedione derivatives of the formula (I): ##STR1## wherein R.sup.1 is hydrogen or a hydrocarbon residue which may be substituted; R.sup.2 is hydrogen, halogen, nitro, optionally substituted amino, formyl or a hydrocarbon residue which may be substituted; R.sup.3 is a hydrocarbon residue which may be substituted; R.sup.4 is hydrogen, halogen or nitro; R.sup.5 is a residue capable of forming an anion or a residue convertible into an anion; X is a direct bond or a spacer having one atomic length and containing an oxygen, nitrogen or sulfur atom; Y is a direct bond or a spacer having atomic length of two or less between the phenylene group and the phenyl group; n is an integer of 1 or 2; and the pharmaceutically acceptable salts thereof have potent angiotensin II antagonistic activity and hypotensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases, strokes, etc.

REFERENCES:
patent: 4880804 (1989-11-01), Carini et al.

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