Phenylaliphatylaminoalkanediphosphonic acids

Details Phenylaliphatylaminoalkanediphosphonic acids Phenylaliphatylaminoalkanediphosphonic acids

1989-11-15

1992-11-10

Evans, Joseph E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

562 13, C07F 938, A61K 31045, A61K 3166

Patent

active

051623102

ABSTRACT:
Phenylaliphatylaminoalkanediphosphonic acids of the formula ##STR1## in which R.sub.1 is an aliphatic hydrocarbon radical having 4 and not more than 7 C atoms and substituted by phenyl, R.sub.2 is a monovalent aliphatic hydrocarbon radical having 1 and not more than 4 C atoms and alk is a divalent aliphatic hydrocarbon radical having 2 and not more than 4 C atoms, and their salts, have a particularly pronounced regulating action on calcium metabolism and can be used as medicaments for the treatment of diseases to be attributed to disturbances thereof. They are prepared, for example, for reacting a compound of the formula ##STR2## in which X.sub.3 denotes carboxyl, with a phosphorylating agent and hydrolyzing the primary product.

REFERENCES:
patent: 3683080 (1972-08-01), Francis
patent: 4927814 (1990-05-01), Cole et al.
Derwent Abstract 88-008486/02 of EP 252504.
Abstract of EP-272208 & corresponding N08704860, Derwent No. 88-169460/25.

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