Certain chloroamino esters of pyridine carboxylates and derivati

Details Certain chloroamino esters of pyridine carboxylates and derivati Certain chloroamino esters of pyridine carboxylates and derivati

1975-11-14

1977-07-19

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260295R, 2602955R, 260477, 260490, 260404, 260611R, 260615A, 424263, 424309, 424311, C07D21380, C07D21379

Patent

active

040368432

ABSTRACT:
There is provided, a novel class of compounds exhibiting antibacterial activity and having the formula: ##STR1## wherein X and Y each represent a member which may be the same or different selected from the group consisting of H and Cl with the proviso that X and Y cannot represent H simultaneously; R.sub.1 and R.sub.2 each represent a member which may be the same or different selected from the group consisting of an n- or branched alkyl group of from 1 to 20 carbon atoms, an aryl group (phenyl, naphthyl, etc.) and a ##STR2## GROUP, WHEREIN M REPRESENTS AN INTEGER OF FROM 2 TO 5; N REPRESENTS AN INTEGER OF 1 TO 8; AND Z represents a member selected from the group consisting of an --OOCR.sub.3 group, an --OR.sub.3 group and an --OCH.sub.2 OR.sub.3 group, wherein R.sub.3 represents a member selected from the group consisting of an n- or branched alkyl group of 1 to 20 carbon atoms, a phenyl group, a naphthyl group, a benzyl group, ##STR3## WHEREIN X is a halogen atom (Cl, Br, I), ##STR4## WHEREIN R.sub.4 represents a member selected from the group consisting of H, an n- or branched alkyl group, a benzyl group, and a --(CH.sub.2).sub.p COOH group, wherein p represents an integer of 1 to 4, and wherein W.sup.- represents a non-toxic pharmaceutically acceptable inorganic or organic anion.

REFERENCES:
patent: 3830806 (1974-08-01), Raabe et al.
Karrer. Organic Chemistry, 4th English Edition, Elsevier Pub. Co. (N.Y. p. 928, (1950).
Kazuo et al., Chem. Abstracts, vol. 80 (1) Item 789r Jan. 7, 1974.
Takeo, Chem. Abstracts, vol. 80 (23) Item No. 129,249u June 10, 1974.

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