Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-02-10
1993-11-16
Chan, Nicky
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549363, A61K 31335, C07D31908
Patent
active
052624358
ABSTRACT:
A new Zaragozic acid analog has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.
REFERENCES:
patent: 5026554 (1991-06-01), Bartizal et al.
patent: 5053425 (1991-10-01), Bartizal et al.
patent: 5055487 (1991-06-01), Bartizal et al.
Baxter et al, Squalestatin 1, A Potent Inhibitor of Squalene Synthase Which Lowers Serum Cholesterol in Vivo, J. Biol. Chem., vol. 267, pp. 11705-11708 (1992).
Harris Guy H.
Joshua Henry
Chan Nicky
DiPrima Joseph F.
Merck & Co. , Inc.
Winokur Melvin
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