Indolo[2,3-a]quinolizines

Details Indolo[2,3-a]quinolizines Indolo[2,3-a]quinolizines

1975-09-17

1977-11-08

Ford, John M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029353, 2602949, 424267, C07D47102, C07D45502

Patent

active

040575519

ABSTRACT:
New compounds of the general formula (I) ##STR1## wherein R stands for an alkyl group, have been prepared by reducing a compound of the general formula (II) ##STR2## wherein R stands for alkyl, B stands for H.sub.2 O or an X.sup.- anion derived from an acid, and if B is an X.sup.- anion, A represents hydrogen, whereas if B is H.sub.2 O, A represents an electron pair. If desired, the racemic compounds of the general formula (I) can be resolved to yield the corresponding optically active isomers. The free bases of the general formula (I) can be converted into their pharmaceutically acceptable salts, or the salts can be treated with an alkaline agent to yield the free bases.
The compounds of the general formula (I) can be used in the therapy primarily as vasodilatating agents.

REFERENCES:
patent: 3478051 (1969-11-01), Houlihan et al.
patent: 3536725 (1970-10-01), Schut
patent: 3799933 (1974-03-01), Le Men et al.
Szantay et al., Tetrahedron Letters 11, 1405-1407 (1968).

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