Synthesis of thiazole derivatives

Details Synthesis of thiazole derivatives Synthesis of thiazole derivatives

1997-03-11

1998-03-24

Ramsuer, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27738

Patent

active

057314420

ABSTRACT:
preparing the pharmaceutical, famotidine--is produced by mixing in a liquid medium formed from a chemically indifferent organic solvent and water, and under an inert atmosphere, (i) a 2-guanidino-4-halomethylthiazole or a hydrohalide complex thereof, (ii) an S-(2-cyanoethyl)isothiourea or a hydrohalide complex thereof, and (iii) a strong alkali metal base. In lieu of (ii), an alkali metal salt of 2-cyanoethyl-1-thiol can be used, and in such case use of (iii) is optional, but preferable.

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patent: 4496737 (1985-01-01), Hoffman, Jr.
patent: 4562261 (1985-12-01), Hirata et al.
patent: 4609737 (1986-09-01), Hirata et al.
patent: 4835281 (1989-05-01), Bod et al.

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