High affinity TGF.beta. nucleic acid ligands and inhibitors

Details High affinity TGF.beta. nucleic acid ligands and inhibitors High affinity TGF.beta. nucleic acid ligands and inhibitors

1995-06-02

1998-03-24

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 254, 435 6, 435 912, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104, C07H 2102

Patent

active

057314241

ABSTRACT:
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF.beta.. Included in the invention are specific RNA and ssDNA ligands to TGF.beta.1 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGF.beta.1 with its receptor.

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